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Parkinson's illness has been classified into five stages by Hoehn and Yahr. Their classification is based on the severity of symptoms and the degree of disability the patient experiences.

When prescribing therapy, the neurologist will take into account the stage at which the patient is perceived to be, amongst other issues.

Stage 1 is referred to as unilateral disease. The term signifies that only one particular side of the body shows symptoms of Parkinson's disease.

This is considered an early stage of the illness and may final for many years. Neuroprotective therapy is common at this stage. This therapy aims to stop further harm to the nervous program.

Vitamin E was utilized at this stage, but several researchers are of the opinion that this is not really efficient. A selective MAO-B inhibitor referred to as Rasigiline has shown guarantee.

Stage two of Parkinson's disease is labeled bilateral illness. Meaning, symptoms of Parkinson's now show up on both sides of the physique. The illness is regarded to be at Stage two even if there is an insignificant symptom (an occasional tremor, for instance) on the side of the physique that was symptom-free of charge earlier.

Recent therapies at this stage include use of dopamine agonists. Till some years ago, dopamine agonists were employed only at later stages of the illness. At present, researchers are of the view that if such therapy is began earlier, complications from utilizing drugs like Levodopa might not arise at later stages.

The illness is mentioned to be at stage three when symptoms show progression and specially when the patient has difficulty in keeping their posture. Symptoms at this stage include postural instability and falling down.

Traditionally, this is the stage at which dopamine agonists or Levodopa was prescribed, but as talked about above, some of these drugs are now utilised at earlier stages itself.

Stage four occurs when there is an enhance in the severity of symptoms like postural instability and falling. Surgery is one option for remedy at this stage. Surgery can alleviate some of the symptoms. Nevertheless, this is generally advisable only for fairly young patients who are in great overall health otherwise.

Stage 5 is the most sophisticated stage of Parkinson's disease. The patient is usually wheelchair bound. Walking is feasible only with assistance.

Levodopa continues to be a prescribed drug at this stage, along with a COMT inhibitor, which guarantees that the effects final longer. Surgery may also be an alternative, such as pallidotomy, which destroys a tiny group of brain cells. This helps steer clear of the rigidity frequently skilled with Parkinson's disease and could quit tremors as effectively.

One more feasible remedy is deep brain stimulation, where electrodes are implanted into the brain tissue and stimulated with low level electric currents.

The symptoms of Parkinson's illness progress as the patient moves from one stage to the subsequent. Ongoing research is creating new treatment options such as stem cell implants and new drugs. aaron parkinson